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Trigonelline, an alkaloid with potential antidiabetic activity, is an efficient Nrf2 inhibitor capable of blocking Nrf2-dependent proteasome activity and thereby apoptosis protection in pancreatic cancer cells. Treatment of cells with Trigonelline attenuates H2O2 induced cell deaths and improves the antioxidant activity. In addition, Trigonelline regulates the apoptotic gene caspase-3, caspase-9 and anti-apoptotic gene Bcl-2, Bcl-XL during H2O2 induced oxidative stress in H9c2 cells.
| Molecular Weight | 137.14 |
| Formula | C7H7NO2 |
| CAS Number | 535-83-1 |
| Solubility (25°C) | DMSO 6 mg/mL (May need ultrasonic) |
| Storage | 4°C, protect from light |
[1] Minji Choi, et al. Phytother Res. Trigonelline induces browning in 3T3-L1 white adipocytes
[4] Iziar A Ludwig, et al. Food Funct. Coffee: biochemistry and potential impact on health
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