Free shipping on all orders over $ 500


Cat. No. M20668
Trifluoperazine Structure

NSC-17474, RP-7623, SKF-5019

Size Price Availability
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Trifluoperazine is an FDA-approved antipsychotic drug for schizophrenia. It is an inhibitor of calmodulin (CaM) and Dopamine D2 receptor with an IC50 value of 1.2 nM for D2 receptor.

Chemical Information
Molecular Weight 407.5
Formula C21H24F3N3S
CAS Number 117-89-5
Solubility (25°C)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Luana E Piccini, et al. Arch Virol. Inhibition of dengue virus infection by trifluoperazine

[2] Zizi Jing, et al. Tohoku J Exp Med. Trifluoperazine Synergistically Potentiates Bortezomib-Induced Anti-Cancer Effect in Multiple Myeloma via Inhibiting P38 MAPK/NUPR1

[3] Magdolna Tardy, et al. Cochrane Database Syst Rev. Trifluoperazine versus low-potency first-generation antipsychotic drugs for schizophrenia

[4] Kai Koch, et al. Cochrane Database Syst Rev. Trifluoperazine versus placebo for schizophrenia

[5] L O Marques, et al. Cochrane Database Syst Rev. Trifluoperazine for schizophrenia

Related Dopamine Receptor Products

TAK-906 is a peripherally restricted, non-BBB permeable molecule that targets the posterior region of the stomach and vomiting center for the study of gastric cramps.


LY3154885 is an orally active dopamine D1 receptor orthosteric modulator (PAM).


ONC206 is a selective antagonist of dopamine D2-like receptor (DRD2) and has broad-spectrum anti-tumor activity.

Tiapride Hydrochloride

Tiapride is a drug that selectively blocks D2 and D3 dopamine receptors in the brain and is used to treat a variety of neurological and psychiatric disorders.

Melitracen hydrochloride

Melitracen hydrochloride is a potential dopamine D1/2 receptor antagonist which has antidepressant properties.

Abmole Inhibitor Catalog

Keywords: Trifluoperazine, NSC-17474, RP-7623, SKF-5019 supplier, Dopamine Receptor, inhibitors, activators

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.