Trifluoperazine is an FDA-approved antipsychotic drug for schizophrenia. It is an inhibitor of calmodulin (CaM) and Dopamine D2 receptor with an IC50 value of 1.2 nM for D2 receptor.
Molecular Weight | 407.5 |
Formula | C21H24F3N3S |
CAS Number | 117-89-5 |
Solubility (25°C) | |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Luana E Piccini, et al. Arch Virol. Inhibition of dengue virus infection by trifluoperazine
[4] Kai Koch, et al. Cochrane Database Syst Rev. Trifluoperazine versus placebo for schizophrenia
[5] L O Marques, et al. Cochrane Database Syst Rev. Trifluoperazine for schizophrenia
Related Dopamine Receptor Products |
---|
TAK-906
TAK-906 is a peripherally restricted, non-BBB permeable molecule that targets the posterior region of the stomach and vomiting center for the study of gastric cramps. |
LY3154885
LY3154885 is an orally active dopamine D1 receptor orthosteric modulator (PAM). |
ONC206
ONC206 is a selective antagonist of dopamine D2-like receptor (DRD2) and has broad-spectrum anti-tumor activity. |
Tiapride Hydrochloride
Tiapride is a drug that selectively blocks D2 and D3 dopamine receptors in the brain and is used to treat a variety of neurological and psychiatric disorders. |
Melitracen hydrochloride
Melitracen hydrochloride is a potential dopamine D1/2 receptor antagonist which has antidepressant properties. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.