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Trifluoperazine

Cat. No. M20668
Trifluoperazine Structure
Synonym:

NSC-17474, RP-7623, SKF-5019

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Biological Activity

Trifluoperazine is an FDA-approved antipsychotic drug for schizophrenia. It is an inhibitor of calmodulin (CaM) and Dopamine D2 receptor with an IC50 value of 1.2 nM for D2 receptor.

Chemical Information
Molecular Weight 407.5
Formula C21H24F3N3S
CAS Number 117-89-5
Solubility (25°C)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Luana E Piccini, et al. Arch Virol. Inhibition of dengue virus infection by trifluoperazine

[2] Zizi Jing, et al. Tohoku J Exp Med. Trifluoperazine Synergistically Potentiates Bortezomib-Induced Anti-Cancer Effect in Multiple Myeloma via Inhibiting P38 MAPK/NUPR1

[3] Magdolna Tardy, et al. Cochrane Database Syst Rev. Trifluoperazine versus low-potency first-generation antipsychotic drugs for schizophrenia

[4] Kai Koch, et al. Cochrane Database Syst Rev. Trifluoperazine versus placebo for schizophrenia

[5] L O Marques, et al. Cochrane Database Syst Rev. Trifluoperazine for schizophrenia

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Keywords: Trifluoperazine, NSC-17474, RP-7623, SKF-5019 supplier, Dopamine Receptor, inhibitors, activators

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