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Trapidil

Cat. No. M8221

All AbMole products are for research use only, cannot be used for human consumption.

Trapidil Structure
Synonym:

AR-12008

Size Price Availability Quantity
5mg USD 50  USD50 In stock
10mg USD 75  USD75 In stock
50mg USD 200  USD200 In stock
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Quality Control & Documentation
Biological Activity

Terapidil is an antiplatelet compound that partially acts as a competitive inhibitor of phosphodiesterase inhibitors and platelet-derived growth factor (PDGF) receptors. Tropidil has vasodilation and NO release effect, which may alleviate tissue injury to some extent. Trepatil inhibits raf-1 / extracellular signal-regulated kinase (ERK) by inhibiting platelet-derived growth factor (PDGF) -induced proliferation of vascular smooth muscle cells (VSMC) through cAMP/ protein kinase A (PKA). In addn. Trampidil inhibited the activation of RhoA/ROCK by cAMP/PKA.

Chemical Information
Molecular Weight 205.26
Formula C10H15N5
CAS Number 15421-84-8
Solubility (25°C) Water ≥ 50 mg/mL
DMSO 50 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Yilin Wang, et al. Trapidil determines the fate of RHF rats through inhibition of ER stress

[2] Bongjun Kim, et al. Trapidil induces osteogenesis by upregulating the signaling of bone morphogenetic proteins

[3] Patrick Trck, et al. Trapidil improves hemodynamic, echocardiographic and redox state parameters of right ventricle in monocrotaline-induced pulmonary arterial hypertension model

[4] Sun-Don Kim, et al. Trapidil, a platelet-derived growth factor antagonist, inhibits osteoclastogenesis by down-regulating NFATc1 and suppresses bone loss in mice

[5] Mazhar Khan, et al. Intrepide; Trapidil eluting stent

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Keywords: Trapidil, AR-12008 supplier, inhibitors, activators

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