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Trans-crocetin (Croceic Acid) is an NMDA receptor antagonist with high affinity, extracted from saffron (Crocus sativus L.). Transcrocetin is capable of crossing the blood-brain barrier and reach the central nervous system (CNS). Transcrocetin at higher concentrations (40-160 µM) reduces significantly cellular viability.
*The compound is unstable in solutions, freshly prepared is recommended
| Molecular Weight | 328.4 |
| Formula | C20H24O4 |
| CAS Number | 27876-94-4 |
| Solubility (25°C) | Water DMSO |
| Storage | -20°C, sealed |
| Related NMDA Products |
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| GluN1 (356-385)
GluN1 (356-385) is an antigenic peptide against N-methyl-D-aspartate receptor (NMDAR) encephalitis. GluN1 (356-385) has the effect of reducing the density of surface NMDAR clusters in hippocampal neurons. |
| Glypromate acetate
Glypromate acetate is a neuroactive peptide with a potent action on acetylcholine release. Glypromate (Gly-Pro-Glu) is a weak NMDA receptor agonist binds to N-methyl-D-aspartate (NMDA) receptor with an IC50 value of 14.7 μM. |
| Radiprodil (RGH-896)
Radiprodil (also known as RGH-896) is an orally active and selective NMDA receptors antagonist which was evaluated as potential treatment of neuropathic pain associated with diabetic peripheral neuropathy (DPNP). |
| L-Glutamic acid monosodium salt hydrate
L-Glutamic acid monosodium salt hydrate is also a Kainate receptor, NMDA receptor and quisqualate receptor agonist; an excitatory amino acid neurotransmitter. |
| Putrescine dihydrochloride
Binds to the polyamine modulatory site of the NMDA receptor and potentiates NMDA-induced currents; precursor of spermidine. |
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