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Glypromate acetate is a neuroactive peptide with a potent action on acetylcholine release. Glypromate acetate is a weak NMDA receptor agonist binds to N-methyl-D-aspartate (NMDA) receptor with an IC50 value of 14.7 μM.
Glypromate (0-100 μM) potentiates the potassium evoked release of both acetylcholine and dopamine, increases K+ evoked acetylcholine release even at concentrations of 0.1 nM and significantly enhances evoked dopamine release.
In vivo, Glypromate (300 mg; i.p. once per day; on day 0, 6 and 12) shows an in vivo effect protecting the temporal cortical somatostatinergic system from Abeta insult. Glypromate acetate can be used for the research of neuroprotection.
| Molecular Weight | 361.35 |
| Formula | C14H23N3O8 |
| CAS Number | 32302-76-4 (free base) |
| Solubility (25°C) | Water 1 mg/mL DMSO 3 mg/mL |
| Storage | -20°C, dry, sealed |
| Related NMDA Products |
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| GluN1 (356-385)
GluN1 (356-385) is an antigenic peptide against N-methyl-D-aspartate receptor (NMDAR) encephalitis. GluN1 (356-385) has the effect of reducing the density of surface NMDAR clusters in hippocampal neurons. |
| Radiprodil (RGH-896)
Radiprodil (also known as RGH-896) is an orally active and selective NMDA receptors antagonist which was evaluated as potential treatment of neuropathic pain associated with diabetic peripheral neuropathy (DPNP). |
| Trans-crocetin
Trans-crocetin (Croceic Acid) is a blood-brain barrier-permeable NMDA receptor antagonist with high affinity, extracted from saffron (Crocus sativus L.). *The compound is unstable in solutions, freshly prepared is recommended |
| L-Glutamic acid monosodium salt hydrate
L-Glutamic acid monosodium salt hydrate is also a Kainate receptor, NMDA receptor and quisqualate receptor agonist; an excitatory amino acid neurotransmitter. |
| Putrescine dihydrochloride
Binds to the polyamine modulatory site of the NMDA receptor and potentiates NMDA-induced currents; precursor of spermidine. |
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