Tosufloxacin tosylate hydrate is a fluoroquinolone antibacterial agent used to treat susceptible infections.
| Molecular Weight | 594.56 |
| Formula | C19H15F3N4O3.C7H8O3S.H2O |
| CAS Number | 1400591-39-0 |
| Solubility (25°C) | DMSO ≥ 20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related Antibiotic Products |
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| Carumonam
Carumonam (AMA-1080) is a sulfonated monocyclic β-lactam antibiotic from Chromobacterium purpureum that targets penicillin-binding proteins (PBPs), is active against aerobic Gram-negative bacteria and is resistant to β-lactamase-mediated hydrolysis. |
| Miocamycin
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| Bialaphos Sodium Salt
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| Plazomicin Sulfate
Plazomicin Sulfate is a derivative of Sisomicin and a novel aminoglycoside antibiotic that binds to the bacterial 30S ribosomal subunit, thereby inhibiting protein synthesis in a concentration-dependent manner, with broad-spectrum antimicrobial activity against aerobic Gram-negative bacteria, and can be used in studies related to pyelonephritis. |
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