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TMP920 is a highly potent and selective RORγt antagonist. TMP920 inhibits RORγt binding to the SRC1 peptide with an IC50 of 0.03 μM.
| Molecular Weight | 454.56 |
| Formula | C29H30N2O3 |
| CAS Number | 1421837-45-7 |
| Form | Solid |
| Solubility (25°C) | DMSO 62.5 mg/mL (ultrasonic) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Jacob S Lee, et al. Immunity. The emerging landscape of RORγt biology
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