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TMN 355 is a potent cyclophilin A inhibitor (IC50 = 1.52 nM). Approximately 27 times more potent than cyclosporin A.
| Cell Experiment | |
|---|---|
| Cell lines | |
| Preparation method | |
| Concentrations | |
| Incubation time | |
| Animal Experiment | |
|---|---|
| Animal models | 8-week-old male C57/BL6 MCD diet mice |
| Formulation | vehicle (DMSO) |
| Dosages | 10 mg/kg or 20 mg/kg |
| Administration | intraperitoneally |
| Molecular Weight | 380.8 |
| Formula | C21H14ClFN2O2 |
| CAS Number | 1186372-20-2 |
| Solubility (25°C) | DMSO 15.23 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Cyclophilin Products |
|---|
| Rencofilstat
Rencofilstat (CRV431) is a cyclosporine derivative as well as an orally active cycloheximide (CYPA) inhibitor for studies related to non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma. |
| CypD-IN-3
CypD-IN-3 is a potent and subtype-selective cyclophilin D (CypD) inhibitor. CypD-IN-3 has CypD affinity with an IC50 value of 0.01 μM. CypD-IN-3 can be used for the research of several diseases including oxidative stress, neurodegenerative disorders, liver diseases, aging, autophagy and diabetes. |
| ASP5286
ASP5286 is a novel non-immune cyclophilin inhibitor for the study of HCV. |
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