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Ticlopidine

Cat. No. M20748
Ticlopidine Structure
Synonym:

Yuclid, Ticlopidinum, Ticlopidina

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Quality Control & Documentation
Biological Activity

Ticlopidine (Yuclid, Ticlopidinum, Ticlopidina) is an orally active inhibitor of platelet aggregation induced by adenosine diphosphate (ADP). Ticlopidine is also an inhibitor of CYP2B6 with Ki of 0.2 μM.

Chemical Information
Molecular Weight 263.79
Formula C14H14ClNS
CAS Number 55142-85-3
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] P Flores-Runk, et al. Ann Pharmacother. Ticlopidine and antiplatelet therapy

[2] J P Desager. Clin Pharmacokinet. Clinical pharmacokinetics of ticlopidine

[3] D V Preobrazhenskiĭ, et al. Ter Arkh. [Ticlopidine]

[4] E Saltiel, et al. Drugs. Ticlopidine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in platelet-dependent disease states

[5] No authors listed. Lancet. Ticlopidine

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  Catalog
Abmole Inhibitor Catalog




Keywords: Ticlopidine, Yuclid, Ticlopidinum, Ticlopidina supplier, Cytochrome P450 (e.g. CYP17), inhibitors, activators


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