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(Thr4,Gly7)-Oxytocin

Cat. No. M10282
(Thr4,Gly7)-Oxytocin Structure
Size Price Availability
10mg USD 300  USD300 1-2 Weeks
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Quality Control & Documentation
Biological Activity

(Thr4,Gly7)-Oxytocin is a peptide. 

Sequence: Cys-Tyr-Ile-Thr-Asn-Cys-Gly-Leu-Gly-NH2

Chemical Information
Molecular Weight 940.1
Formula C39H61N11O12S2
CAS Number 60786-59-6
Storage -20°C, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Binqi Hu, et al. Cereb Cortex. Activation of Oxytocin Receptors Excites Subicular Neurons by Multiple Signaling and Ionic Mechanisms

[2] J Elands, et al. Am J Physiol. [3H]-[Thr4,Gly7]OT: a highly selective ligand for central and peripheral OT receptors

[3] J Lowbridge, et al. J Med Chem. Synthesis and some pharmacological properties of [4-threonine, 7-glycine]oxytocin, [1-(L-2-hydroxy-3-mercaptopropanoic acid), 4-threonine, 7-glycine]oxytocin (hydroxy[Thr4, Gly7]oxytocin), and [7-Glycine]oxytocin, peptides with high oxytocic-antidiuretic 䲧睉Ỵ睊㧀睈

[4] Lily R Barrett, et al. Neuropsychopharmacology. Oxytocin activation of paraventricular thalamic neurons promotes feeding motivation to attenuate stress-induced hypophagia

[5] Jordi Altirriba, et al. Endocrinology. Divergent effects of oxytocin treatment of obese diabetic mice on adiposity and diabetes

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