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Thiorphan was a selective neprilysin inhibitor with an IC50 value of 6.9 nM. Increased bradykinin-induced relaxation of isolated porcine coronary rings with potassium chloride precontraction under hypoxic but very oxygen conditions.
| Molecular Weight | 253.32 |
| Formula | C12H15NO3S |
| CAS Number | 76721-89-6 |
| Solubility (25°C) | Ethanol: 50 mg/mL DMSO: 30 mg/mL |
| Storage | -20°C |
[3] Christopher Stewart Heather. BMJ Clin Evid. Travellers' diarrhoea
[4] R Greenberg, et al. Life Sci. Thiorphan potentiation of stress-induced analgesia in the mouse
| Related Neprilysin (NEP) Products |
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| Opiorphin
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| Sacubitril
Sacubitril (AHU-377) is a potent NEP inhibitor with an IC50 of 5 nM. Sacubitril (AHU-377) is a component of the heart failure medicine LCZ696. |
| LBQ657
LBQ657 is an active metabolite of Sacubitril and an inhibitor of enkephalinase (NEP). |
| Omapatrilat
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| Phosphoramidon disodium salt
Phosphoramidon disodium salt is a microbial metabolite and an inhibitor of the specific metalloproteases thermolysin, endothelin-converting enzyme (ECE), neutralizing peptidase (NEP) and angiotensin-converting enzyme (ACE), with IC50s of 0.4 μg/mL, 3.5 μM, 0.034 μM and 78 μM, respectively. Phosphoramidon disodium salt also prevented the degradation of amyloid β-peptide and increased Aβ levels in rodents. |
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