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Thioacetazone inhibits mycolic acid cyclopropane synthase but the exact binding site accounting for such inhibition is presently unknown. Thiacetazone (TAC) inhibits the conversion of double bonds of mycolic acid precursors into cyclopropyl rings in Mycobacterium bovis var BCG, M. marimum and M. chelonae by affecting the cyclopropyl mycolic acid synthases (CMASs) as judged by the build-up of unsaturated mycolate precursors.
| Molecular Weight | 236.29 |
| Formula | C10H12N4OS |
| CAS Number | 104-06-3 |
| Solubility (25°C) | DMSO 10 mM |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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