Theaflavin is a natural influenza A (H1N1) neuraminidase inhibitor.
 |
Source | PLoS One (2015). Figure 3. Theaflavin |
| Method | black tea extract | |
| Cell Lines | epithelial cells | |
| Concentrations | 50 and 200 μg/ml | |
| Incubation Time | 48 h | |
| Results | While theaflavin did not induce the secretion of significant amounts of hBDs by oral epithelial cells, theaflavin-3,3’-digallate at 75 μg/ml and 100 μg/ml was able to significantly induce the secretion of hBD-1 and hBD-2. |
 |
Source | PLoS One (2015). Figure 2. Theaflavin |
| Method | black tea extract | |
| Cell Lines | epithelial cells | |
| Concentrations | 50 and 200 μg/ml | |
| Incubation Time | 48 h | |
| Results | More specifically, the black tea extract (200 μg/ml), as well as theaflavin and theaflavin-3,3’-digallate (50 μg/ml) reduced IL-8 secretion by 85%, 79%, and 86%, respectively. |
| Cell Experiment | |
|---|---|
| Cell lines | OBA-9 cells |
| Preparation method | OBA-9 cells were treated with the black tea extract (150 and 200 μg/ml), theaflavin (75 and 100 μg/ml), theaflavin-3,3’-digallate (75 and 100 μg/ml) or EGCG (100 μg/ml) for 48 h at 37°C in a 5% CO2 atmosphere. Following stimulation, the supernatants were collected, centrifuged (500 x g for 5 min) and stored at -80°C until used. |
| Concentrations | 75 and 100 μg/ml |
| Incubation time | 48 h |
| Animal Experiment | |
|---|---|
| Animal models | nude mice |
| Formulation | PBS |
| Dosages | 10 mg/kg/d |
| Administration | i.v. |
| Molecular Weight | 564.49 |
| Formula | C29H24O12 |
| CAS Number | 4670-05-7 |
| Form | Solid |
| Solubility (25°C) | DMSO ≥ 100 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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