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Recombinant Mouse TGF-beta 1 Protein (Human Cells)

Cat. No. M10922
Recombinant Mouse TGF-beta 1 Protein (Human Cells) Structure
Synonym:

TGF-β1, Mouse

Size Price Availability Quantity
10ug USD 400  USD400 In stock
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Quality Control & Documentation
  • Purity: >95%, Endotoxin < 1 EU/μg
  • COA
  • MSDS
Biological Activity

TGF-beta 1 protein, Mouse is a multifunctional cytokine that controls many biological processes including immunity, differentiation, tumor suppression, tumor metastasis, aging, migration, wound healing, apoptosis, cell division, adipogenesis, and osteogenesis.

ED50 is 5-25 pg/ml, measured by its ability to inhibit IL-4-dependent proliferation of TF-1 human erythroleukemic cells.


Accession # P04202

Apparent Molecular Weight: ~12.8 kDa, reducing conditions

Endotoxin < 1 EU/μg

Lyophilized from a 0.2 μm filtered solution in 4 mM HCl.

Product Citations
Chemical Information
Form Lyophilized powder
Solubility (25°C) Reconstitute the lyophilized powder in ddH2O up to 100 μg/ml
Storage Stable for up to 6 months at ≤ -20°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yen-Ting Chen, et al. J Clin Invest. Endoplasmic reticulum protein TXNDC5 promotes renal fibrosis by enforcing TGF-β signaling in kidney fibroblasts

[2] Kevin K Kim, et al. Cold Spring Harb Perspect Biol. TGF-β1 Signaling and Tissue Fibrosis

[3] Xiaomeng Wang, et al. Nature. LRG1 promotes angiogenesis by modulating endothelial TGF-β signalling

[4] Daisuke Sugiyama, et al. Mech Dev. TGF-beta-1 up-regulates extra-cellular matrix production in mouse hepatoblasts

[5] Li Xiao, et al. Front Biosci (Landmark Ed). TGF-beta 1 induced fibroblast proliferation is mediated by the FGF-2/ERK pathway

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Keywords: Recombinant Mouse TGF-beta 1 Protein (Human Cells), TGF-β1, Mouse supplier, Recombinant Proteins, inhibitors, activators


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