TGF-beta 1 protein, Mouse is a multifunctional cytokine that controls many biological processes including immunity, differentiation, tumor suppression, tumor metastasis, aging, migration, wound healing, apoptosis, cell division, adipogenesis, and osteogenesis.
ED50 is 5-25 pg/ml, measured by its ability to inhibit IL-4-dependent proliferation of TF-1 human erythroleukemic cells.
Dig Liver Dis. 2021 Dec 10;S1590-8658(21)00843-4.
Long noncoding RNA GAS5 inhibits LX-2 cells activation by suppressing NF-κB signalling through regulation of the miR-433–3p/TLR10 axis
Recombinant Mouse TGF-beta 1 Protein (Human Cells) purchased from AbMole
|Solubility (25°C)||Reconstitute the lyophilized powder in ddH₂O up to 100 μg/ml|
Powder -20°C 3 years ; 4°C 2 years
In solvent -80°C 6 months ; -20°C 1 month
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
 Yen-Ting Chen, et al. J Clin Invest. Endoplasmic reticulum protein TXNDC5 promotes renal fibrosis by enforcing TGF-β signaling in kidney fibroblasts
 Kevin K Kim, et al. Cold Spring Harb Perspect Biol. TGF-β1 Signaling and Tissue Fibrosis
 Xiaomeng Wang, et al. Nature. LRG1 promotes angiogenesis by modulating endothelial TGF-β signalling
 Daisuke Sugiyama, et al. Mech Dev. TGF-beta-1 up-regulates extra-cellular matrix production in mouse hepatoblasts
 Li Xiao, et al. Front Biosci (Landmark Ed). TGF-beta 1 induced fibroblast proliferation is mediated by the FGF-2/ERK pathway
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