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TGF-beta 1 Protein, Mouse (Human Cells)

Cat. No. M10922
TGF-beta 1 Protein, Mouse (Human Cells) Structure
Synonym:

TGF-β1, Mouse

Size Price Availability Quantity
10 μg USD 320  USD400 In stock
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Quality Control
  • Current batch:
  • Purity >95%, Endotoxin < 1 EU/μg
  • COA
  • MSDS
Biological Activity

TGF-beta 1 protein, Mouse is a multifunctional cytokine that controls many biological processes including immunity, differentiation, tumor suppression, tumor metastasis, aging, migration, wound healing, apoptosis, cell division, adipogenesis, and osteogenesis. 

ED50 is 5-25 pg/ml, measured by its ability to inhibit IL-4-dependent proliferation of TF-1 human erythroleukemic cells.

Product Citations
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight
Formula
CAS Number
Purity >95%, Endotoxin < 1 EU/μg
Solubility Reconstitute the lyophilized powder in ddH₂O up to 100 μg/ml
Storage at -20°C
References

[1] Yen-Ting Chen, et al. J Clin Invest. Endoplasmic reticulum protein TXNDC5 promotes renal fibrosis by enforcing TGF-β signaling in kidney fibroblasts

[2] Kevin K Kim, et al. Cold Spring Harb Perspect Biol. TGF-β1 Signaling and Tissue Fibrosis

[3] Xiaomeng Wang, et al. Nature. LRG1 promotes angiogenesis by modulating endothelial TGF-β signalling

[4] Daisuke Sugiyama, et al. Mech Dev. TGF-beta-1 up-regulates extra-cellular matrix production in mouse hepatoblasts

[5] Li Xiao, et al. Front Biosci (Landmark Ed). TGF-beta 1 induced fibroblast proliferation is mediated by the FGF-2/ERK pathway

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Keywords: TGF-beta 1 Protein, Mouse (Human Cells), TGF-β1, Mouse supplier, Cytokines, inhibitors

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