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Tetrahydropalmatine hydrochloride

Cat. No. M13953
Tetrahydropalmatine hydrochloride Structure

DL-Tetrahydropalmatine hydrochloride

Size Price Availability Quantity
10mg USD 70  USD70 In stock
50mg USD 105  USD105 In stock
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Quality Control & Documentation
Biological Activity

Tetrahydropalmatine (DL-Tetrahydropalmatine) hydrochloride possesses analgesic effects. Tetrahydropalmatine hydrochloride acts through inhibition of amygdaloid release of dopamine to inhibit an epileptic attack in rats.

Chemical Information
Molecular Weight 391.89
CAS Number 6024-85-7
Solubility (25°C) DMSO 25 mg/mL
Water 4 mg/mL (ultrasonic and warming and heat to 60°C)
Storage 2-8°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Weijian Li, et al. Total Synthesis of (-)-Canadine, (-)-Rotundine, (-)-Sinactine, and (-)-Xylopinine Using a Last-Step Enantioselective Ir-Catalyzed Hydrogenation

[2] Zhihao Deng, et al. Identification of the active ingredients from Guangtongxiao decoction in rat bile based on ultra-performance liquid chromatography/Synapt G2 quadrupole time-of-flight tandem mass spectrometry

[3] Yongping Zhang, et al. Optimization of the extraction and purification of Corydalis yanhusuo W.T. Wang based on the Q-marker uniform design method

[4] Jing Lu, et al. Separation of Berberine Hydrochloride and Tetrahydropalmatine and Their Quantitative Analysis with Thin Layer Chromatography Involved with Ionic Liquids

[5] Yuan-yuan Lin, et al. Plasma pharmacokinetics and lung distribution of tetrahydropalmatine after topical application of cold asthma recipe extract: Feishu (BL 13) versus Non-Feishu acupoint

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Keywords: Tetrahydropalmatine hydrochloride, DL-Tetrahydropalmatine hydrochloride supplier, Dopamine Receptor, inhibitors, activators

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