Tetrahydropalmatine (DL-Tetrahydropalmatine) hydrochloride possesses analgesic effects. Tetrahydropalmatine hydrochloride acts through inhibition of amygdaloid release of dopamine to inhibit an epileptic attack in rats.
| Molecular Weight | 391.89 |
| CAS Number | 6024-85-7 |
| Solubility (25°C) | DMSO 25 mg/mL Water 4 mg/mL (ultrasonic and warming and heat to 60°C) |
| Storage | 2-8°C, protect from light, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related Dopamine Receptor Products |
|---|
| D-Tetrahydropalmatine
D-Tetrahydropalmatine is an isoquinoline alkaloid, mainly in the genus Corydalis. |
| Ensaculin free base
Ensaculin free base (KA-672) is a NMDA antagonist and have high affinities to serotonergic 5-HT1A and 5-HT7 receptors, adrenergic α1, and dopaminergic D2 and D3 receptors. |
| NPEC-caged-dopamine
NPEC-caged-dopamine is a caged version of dopamine. |
| D4R agonist-1
D4R agonist-1 is a D4R partial agonist (Ki: 2.2 nM). |
| SKF 83822
SKF 83822 is an atypical agonist of dopamine D1 receptor. |
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