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Tetracosactide

Cat. No. M54484
Tetracosactide Structure
Synonym:

Cosyntropin

Size Price Availability Quantity
5mg USD 240  USD240 In stock
10mg USD 380  USD380 In stock
25mg USD 720  USD720 In stock
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Quality Control & Documentation
Biological Activity

Tetracosactide (Tetracosactrin) is an analogue of adrenocorticotrophic hormone (ACTH), Tetracosactide can stimulate the release of corticosteroids such as cortisol from the adrenal gland.

Chemical Information
Molecular Weight 2933.44
Formula C136H210N40O31S
CAS Number 16960-16-0
Form Solid
Solubility (25°C) Water 90 mg/mL
Storage -20°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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Keywords: Tetracosactide, Cosyntropin supplier, inhibitors, activators


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