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We have demonstrated, to the best of our knowledge for the first time, the effects of short (1-day) and prolonged (2-weeks, 10-weeks) in vivo administrations of testosterone enanthate (TE) on molecular markers of pituitary functionality as well as prolactin (PRL) and cAMP signaling in Leydig cells.
| Cell Experiment | |
|---|---|
| Cell lines | Leydig cells |
| Preparation method | For in vitro experiments the primary cultures of purified Leydig cells were isolated from undisturbed rats and plated for monitoring genes expression. After 2 h of recovery, the culture medium was trashed and the Leydig cells were incubated for 20 h without (CUT, untreated (control) cells) or with test osterone (T, 20 μM ) or cyproterone-acetate (CPA, 100 μM ) or combination CPA (100 μM ) + T (20 μM ), or in presence of hCG (5 192 and 50 ng/ml) as a positive control. |
| Concentrations | 20 μM |
| Incubation time | 20 h |
| Animal Experiment | |
|---|---|
| Animal models | male Wistar rats |
| Formulation | |
| Dosages | 0.5mg/100g or 2.5 mg/100g |
| Administration | i.v. |
| Molecular Weight | 400.59 |
| Formula | C26H40O3 |
| CAS Number | 315-37-7 |
| Solubility (25°C) | 10 mM in DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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