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Terlipressin diacetate

Cat. No. M11396
Terlipressin diacetate Structure
Size Price Availability Quantity
5mg USD 50  USD50 In stock
10mg USD 65  USD65 In stock
25mg USD 125  USD125 In stock
100mg USD 255  USD255 In stock
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Quality Control & Documentation
Biological Activity

Terlipressin diacetate is a vasopressin analogue and a highly selective vasopressin V1 receptor agonist that reduces visceral blood flow and portal vein pressure and controls acute varicose rupture bleeding. Terlipressin diacetate has anti-inflammatory and antioxidant effects and can be used to study hepatorenal syndrome and norepinephrine-resistant septic shock.

Chemical Information
Molecular Weight 1347.48
Formula C56H82N16O19S2
CAS Number 1884420-36-3
Solubility (25°C) Water 90 mg/mL
DMSO 45 mg/mL
Storage -20°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Ho-Yen Chueh, et al. Fertil Steril. Hysteroscopic removal, with or without laparoscopic assistance, of first-trimester cesarean scar pregnancy

[2] Rey-Heng Hu, et al. Hepatogastroenterology. Open, randomized, comparative study of efficacy and safety between Haemopressin and Glypressin in treating acute esophageal varices hemorrhage

[3] P U Becker, et al. Ugeskr Laeger. [Terlipressin acetate]

[4] L J Vynckier, et al. J Vet Pharmacol Ther. Plasma ronidazole concentrations in sheep after intravenous, oral, intraruminal and intraabomasal administration

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Keywords: Terlipressin diacetate supplier, Vasopressin Receptor, inhibitors, activators


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