Terbutaline Sulfate is a selective β2-adrenergic receptor agonist with IC50 of 53 nM.
J Thromb Haemost. 2023 Mar 25;S1538-7836(23)00245-3.
β2-AR agonist corrects immune thrombocytopenia by reestablishing the homeostasis of T cell differentiation
Terbutaline Sulfate purchased from AbMole
J Thromb Haemost. 2023 Jul;21(7):1920-1933.
β2-adrenergic receptor agonist corrects immune thrombocytopenia by reestablishing the homeostasis of T cell differentiation
Terbutaline Sulfate purchased from AbMole
Molecular Weight | 548.65 |
Formula | C24H38N2O6.H2O4S |
CAS Number | 23031-32-5 |
Solubility (25°C) | Water ≥ 60 mg/mL |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[3] F Lam, et al. Clinical issues surrounding the use of terbutaline sulfate for preterm labor
[4] D C Lee. Terbutaline sulfate overdose
[5] C H Scoggin. Aerosolized terbutaline sulfate in the treatment of bronchospasm
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