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Temocapril HCl is the hydrochloride of Temocapril, which is a long-acting angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension.
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Source | Clin Exp Pharmacol Physiol (2012). Figure 2. Temocapril HCl |
| Method | MMP-2 activity assay | |
| Cell Lines | ||
| Concentrations | 1 μmol/L and 10 and 100 nmol/L | |
| Incubation Time | 24 h | |
| Results | Temocaprilat inhibited MMP-2 activity in a dose-dependent manner at doses ranging from 10 nmol/L to 1 μmol/L (IC50 0.47 μmol/L). |
| Cell Experiment | |
|---|---|
| Cell lines | Caco-2 cell |
| Preparation method | For the experiments involving the transport of propranolol, naproxen and temocaprilat from the inside to the outside of cells, intact Caco-2 cell monolayers (i.e. untreated with BNPP) were used. |
| Concentrations | 85 mM |
| Incubation time | 5 min |
| Animal Experiment | |
|---|---|
| Animal models | Male Wistar rats |
| Formulation | DMSO |
| Dosages | 10–500 μM |
| Administration | oral |
| Molecular Weight | 513.07 |
| Formula | C23H28N2O5S2.HCl |
| CAS Number | 110221-44-8 |
| Form | Solid |
| Solubility (25°C) | 103 mg/mL in DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related ACE Products |
|---|
| Enalaprilat
Enalaprilat (MK-422 anhydrous), the active metabolite of the oral proagent Enalapril, is a potent, competitive and long-acting angiotensin-converting enzyme (ACE) inhibitor, with an IC50 of 1.94 nM. |
| Deserpidine
Deserpidine (Harmonyl) is an alkaloid isolated from the root of Rauwolfia canescens related to Reserpine. |
| H-Ile-Pro-Pro-OH hydrochloride
H-Ile-Pro-Pro-OH hydrochloride, a milk-derived peptide, inhibits angiotensin-converting enzyme (ACE) with an IC50 of 5 μM. |
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| Bradykinin potentiator B
Bradykinin potentiator B (Bradykinin potentiating peptide B) is venom of Agkistrodon halys blomhoffi. |
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