Tebipenem, the first oral carbapenem antibiotic, inhibits both gram-positive and gram-negative bacteria, but has no effect on Pseudomonas aeruginosa.
Molecular Weight | 383.49 |
Formula | C16H21N3O4S2 |
CAS Number | 161715-21-5 |
Form | Solid |
Solubility (25°C) | DMSO ≥ 20 mg/mL |
Storage | <-20℃ |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[3] Varun Sodhi, et al. Pharmacotherapy. Tebipenem pivoxil hydrobromide-No PICC, no problem!
[4] Akash Jain, et al. Expert Rev Anti Infect Ther. Tebipenem, the first oral carbapenem antibiotic
[5] George G Zhanel, et al. Drugs. Comparative review of the carbapenems
Related Antibiotic Products |
---|
Kendomycin
Kendomycin is a polyketide antibiotic with significant antibacterial activity and tumor cytotoxicity. At low concentrations (MIC: 5 μg/mL), Kendomycin inhibits the growth of methicillin-resistant Staphylococcus aureus (MRSA) strain COL. In addition, Kendomycin is an endothelin receptor antagonist and calcitonin receptor agonist. |
Ceftobiprole
Ceftobiprole is a broad-spectrum cephalosporin with rapid bactericidal activity against Gram-positive bacteria such as Staphylococcus aureus, including methicillin-resistant strains (MRSA), and Gram-negative bacteria, with a MIC90 value of 2 μg/mL against MRSA. |
Showdomycin
Showdomycin is an antibiotic that is induced by IM-2 in Streptomyces. |
Quinupristin
Quinupristin is a streptogramin antibiotic. |
Buforin II
Buforin II, derived from buforin I, a protein isolated from the stomach of the Asian toad Bufo bufo gargarizans, is a potent antimicrobial peptide. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.