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Tebipenem

Cat. No. M13349
Tebipenem Structure
Synonym:

LJC 11036

Size Price Availability Quantity
5mg USD 148  USD148 In stock
10mg USD 235  USD235 In stock
50mg USD 710  USD710 In stock
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Quality Control & Documentation
Biological Activity

Tebipenem, the first oral carbapenem antibiotic, inhibits both gram-positive and gram-negative bacteria, but has no effect on Pseudomonas aeruginosa.

Chemical Information
Molecular Weight 383.49
Formula C16H21N3O4S2
CAS Number 161715-21-5
Form Solid
Solubility (25°C) DMSO ≥ 20 mg/mL
Storage <-20℃
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Paul B Eckburg, et al. N Engl J Med. Oral Tebipenem Pivoxil Hydrobromide in Complicated Urinary Tract Infection

[2] Elli Mylona, et al. J Antimicrob Chemother. Tebipenem as an oral alternative for the treatment of typhoid caused by XDR Salmonella Typhi

[3] Varun Sodhi, et al. Pharmacotherapy. Tebipenem pivoxil hydrobromide-No PICC, no problem!

[4] Akash Jain, et al. Expert Rev Anti Infect Ther. Tebipenem, the first oral carbapenem antibiotic

[5] George G Zhanel, et al. Drugs. Comparative review of the carbapenems

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  Catalog
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