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TC-S 7009

Cat. No. M7392

All AbMole products are for research use only, cannot be used for human consumption.

TC-S 7009 Structure

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Quality Control & Documentation
Biological Activity

TC-S 7009 is a high affinity and selective HIF-2α inhibitor (Kd = 81 nM). Binds to the HIF-2α PAS-B domain; disrupts HIF-2α-ARNT heterodimerization. Exhibits >60-fold selectivity for HIF-2α over HIF-1α. Decreases HIF-2α DNA-binding and attenuates expression of HIF-2α target genes in vitro.

Chemical Information
Molecular Weight 308.65
Formula C12H6ClFN4O3
CAS Number 1422955-31-4
Solubility (25°C) DMSO 30.86 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Zhang, et al. Clin Exp Hypertens. Effects of early captopril treatment and its removal on plasma angiotensin converting enzyme (ACE) activity and arginine vasopressin in hypertensive rats (SHR) and normotensive rats (WKY).

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Keywords: TC-S 7009 supplier, inhibitors, activators

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