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TAT-GluR23A Fusion Peptide

Cat. No. M41188
TAT-GluR23A Fusion Peptide Structure
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Biological Activity

TAT-GluR23A Fusion Peptide is a biological active peptide.

Chemical Information
Molecular Weight 2357.68
Formula C97H173N43O26
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Geetanjali Meher et al. J Membr Biol. Membrane Composition Modulates Fusion by Altering Membrane Properties and Fusion Peptide Structure

[2] Gourab Prasad Pattnaik et al. Adv Exp Med Biol. Exploring the Mechanism of Viral Peptide-Induced Membrane Fusion

[3] Niek S A Crone et al. Int J Mol Sci. Peptide-Mediated Liposome Fusion: The Effect of Anchor Positioning

[4] Volker Schellenberger et al. Nat Biotechnol. A recombinant polypeptide extends the in vivo half-life of peptides and proteins in a tunable manner

[5] K Terpe. Appl Microbiol Biotechnol. Overview of tag protein fusions: from molecular and biochemical fundamentals to commercial systems

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