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TASIN-1 

Cat. No. M30618

All AbMole products are for research use only, cannot be used for human consumption.

TASIN-1  Structure

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Quality Control & Documentation
Biological Activity

TASIN-1 is a selective inhibitor of truncated APC gene (adenomatous polyposis coli gene) and exerts cytotoxic effects through inhibition of cholesterol biosynthesis. TASIN-1 represents a potential therapeutic strategy for prevention and intervention in CRC with mutant APC.

Chemical Information
Molecular Weight 352.49
Formula C18H28N2O3S
CAS Number 792927-06-1
Form Solid
Solubility (25°C) DMSO 25 mg/mL (ultrasonic and warming and heat to 60°C)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Wentian Wang, et al. J Med Chem. Design and Synthesis of TASIN Analogues Specifically Targeting Colorectal Cancer Cell Lines with Mutant Adenomatous Polyposis Coli (APC)

[2] Lu Zhang, et al. Mol Cancer Ther. Cholesterol Depletion by TASIN-1 Induces Apoptotic Cell Death through the ER Stress/ROS/JNK Signaling in Colon Cancer Cells

[3] Megan Cully. Nat Rev Drug Discov. Anticancer drugs: Exploiting a weakness in colorectal cancers

[4] Lu Zhang, et al. Sci Transl Med. Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer

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  Catalog
Abmole Inhibitor Catalog




Keywords: TASIN-1  supplier, inhibitors, activators

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