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TASIN-1 is a selective inhibitor of truncated APC gene (adenomatous polyposis coli gene) and exerts cytotoxic effects through inhibition of cholesterol biosynthesis. TASIN-1 represents a potential therapeutic strategy for prevention and intervention in CRC with mutant APC.
| Molecular Weight | 352.49 |
| Formula | C18H28N2O3S |
| CAS Number | 792927-06-1 |
| Form | Solid |
| Solubility (25°C) | DMSO 25 mg/mL (ultrasonic and warming and heat to 60°C) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Megan Cully. Nat Rev Drug Discov. Anticancer drugs: Exploiting a weakness in colorectal cancers
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