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Takeda-6D (compound 6d) is an orally active and potent BRAF/VEGFR2 inhibitor, with IC50 values of 7.0 and 2.2 nM, respectively. Takeda-6D shows antiangiogenesis by suppressing the VEGFR2 pathway in 293/KDR and VEGF-stimulated HUVEC cells.Takeda-6D shows significant suppression of ERK1/2 phosphorylation. Takeda-6D shows antitumor activity.
| Molecular Weight | 547.99 |
| Formula | C27H19ClFN5O3S |
| CAS Number | 1125632-93-0 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
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