TAK-020

Cat. No. M21189

All AbMole products are for research use only, cannot be used for human consumption.

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Quality Control & Documentation

Purity: >99%
COA
MSDS

Product Information

Biological Activity

TAK-020 is a highly selective oral covalent BTK inhibitor with a promising safety and tolerability profile for both hematologic malignancies and autoimmune diseases.

Chemical Information

Molecular Weight	351.36
Formula	C18H17N5O3
CAS Number	1627603-21-7
Solubility (25°C)	DMSO : 16.67 mg/mL
Storage	Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month

References

[1] Mark Sabat, et al. J Med Chem. Correction to "Discovery of the Bruton's Tyrosine Kinase Inhibitor Clinical Candidate TAK-020 ( S)-5-(1-((1-Acryloylpyrrolidin-3-yl)oxy)isoquinolin-3-yl)-2,4-dihydro-3 H-1,2,4-triazol-3-one, by Fragment-Based Drug Design"

[2] Mark Sabat, et al. J Med Chem. Discovery of the Bruton's Tyrosine Kinase Inhibitor Clinical Candidate TAK-020 ( S)-5-(1-((1-Acryloylpyrrolidin-3-yl)oxy)isoquinolin-3-yl)-2,4-dihydro-3 H-1,2,4-triazol-3-one, by Fragment-Based Drug Design

[3] Ehsanollah Esfandiari, et al. Clin Transl Sci. A Phase I, Randomized, Double-Blind, Placebo-Controlled, Single-Dose and Multiple-Rising-Dose Study of the BTK Inhibitor TAK-020 in Healthy Subjects

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TAK-020

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