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T3MG

Cat. No. M8800

All AbMole products are for research use only, cannot be used for human consumption.

T3MG Structure

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Quality Control & Documentation
Biological Activity

T3MG is a selective inhibitor of excitatory amino acid transporters GLT-1, EAAT2, and EAAT4. T3MG has long been utilized as a gold standard in the study of general EAAT function. It has more recently been shown to be selective for EAAT2 and EAAT4 as compared to EAAT1 and EAAT3 in electrophysiology and glutamate/aspartate uptake assays. Although there are other EAAT2-selective compounds, this is the first tool with selectivity for EAAT4. T3MG is not a substrate for the transporters themselves, nor does it have activity at glutamate ion channels.

Chemical Information
Molecular Weight 161.16
Formula C6H11NO4
CAS Number 63088-04-0
Solubility (25°C) Water: ≥1.5 mg/dL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] S Eliasof, et al. Pharmacological characterization of threo-3-methylglutamic acid with excitatory amino acid transporters in native and recombinant systems

[2] K Brix, et al. Extrathyroidal release of thyroid hormones from thyroglobulin by J774 mouse macrophages

[3] M Sugawara, et al. Thyroid T4 5'-deiodinase activity in normal and abnormal human thyroid glands

[4] D Polk, et al. Nuclear thyroid hormone receptors: ontogeny and thyroid hormone effects in sheep

[5] J Beard, et al. Evidence for thyroid hormone deficiency in iron-deficient anemic rats

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  Catalog
Abmole Inhibitor Catalog




Keywords: T3MG supplier, inhibitors, activators

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