Supercinnamaldehyde is a transient receptor potential ankyrin 1 (TRPA1) activator, with EC50 of 0.8 μM. Supercinnamaldehyde covalently binds to and activates TRPA1 receptor (expressed in nociceptive neurons) by modifying its cysteine residues. Covalent modification of reactive cysteines within TRPA1 can cause channel activation, rapidly signaling potential tissue damage through the pain pathway.
| Molecular Weight | 201.22 |
| Formula | C12H11NO2 |
| CAS Number | 70351-51-8 |
| Solubility (25°C) | DMSO 10 mg/mL |
| Storage | 2-8°C, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Spartak Yanakiev. Effects of Cinnamon ( Cinnamomum spp.) in Dentistry: A Review
[2] Amanda A Doyle, et al. A review of cinnamaldehyde and its derivatives as antibacterial agents
[4] Su-Hyung Hong, et al. Cinnamaldehydes in Cancer Chemotherapy
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