Sulfobromophthalein (Bromosulfophthalein) disodium salt is an organic anion dye used in the study of a variety of membrane carriers expressed in animal tissues and involved in transport of drugs and metabolites.
|Solubility (25°C)||DMSO 250 mg/mL|
|Storage||2-8°C, dry, sealed|
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
 Keiyu Oshida, et al. Eur J Drug Metab Pharmacokinet. Identification of Transporters Involved in Beraprost Sodium Transport In Vitro
 B Hagenbuch, et al. Semin Liver Dis. Sinusoidal (basolateral) bile salt uptake systems of hepatocytes
 P J Meier. Am J Physiol. Molecular mechanisms of hepatic bile salt transport from sinusoidal blood into bile
 S J Burwen, et al. Int Rev Cytol. Subcellular and molecular mechanisms of bile secretion
 J P Capron, et al. Digestion. Barbituates and biliary function
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