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Sulfobromophthalein disodium salt

Cat. No. M13801
Sulfobromophthalein disodium salt Structure
Synonym:

Bromosulfophthalein disodium salt

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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Sulfobromophthalein (Bromosulfophthalein) disodium salt is an organic anion dye used in the study of a variety of membrane carriers expressed in animal tissues and involved in transport of drugs and metabolites.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 838
Formula
CAS Number 71-67-0
Purity >99%
Solubility DMSO 250 mg/mL
Storage 2-8°C, dry, sealed
References

[1] Keiyu Oshida, et al. Eur J Drug Metab Pharmacokinet. Identification of Transporters Involved in Beraprost Sodium Transport In Vitro

[2] B Hagenbuch, et al. Semin Liver Dis. Sinusoidal (basolateral) bile salt uptake systems of hepatocytes

[3] P J Meier. Am J Physiol. Molecular mechanisms of hepatic bile salt transport from sinusoidal blood into bile

[4] S J Burwen, et al. Int Rev Cytol. Subcellular and molecular mechanisms of bile secretion

[5] J P Capron, et al. Digestion. Barbituates and biliary function

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