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Sulfobromophthalein disodium salt

Cat. No. M13801
Sulfobromophthalein disodium salt Structure
Synonym:

Bromosulfophthalein disodium salt

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Biological Activity

Sulfobromophthalein (Bromosulfophthalein) disodium salt is an organic anion dye used in the study of a variety of membrane carriers expressed in animal tissues and involved in transport of drugs and metabolites.

Chemical Information
Molecular Weight 838
CAS Number 71-67-0
Solubility (25°C) DMSO 250 mg/mL
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Keiyu Oshida, et al. Eur J Drug Metab Pharmacokinet. Identification of Transporters Involved in Beraprost Sodium Transport In Vitro

[2] B Hagenbuch, et al. Semin Liver Dis. Sinusoidal (basolateral) bile salt uptake systems of hepatocytes

[3] P J Meier. Am J Physiol. Molecular mechanisms of hepatic bile salt transport from sinusoidal blood into bile

[4] S J Burwen, et al. Int Rev Cytol. Subcellular and molecular mechanisms of bile secretion

[5] J P Capron, et al. Digestion. Barbituates and biliary function

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