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sulfaisodimidine

Cat. No. M19904
sulfaisodimidine Structure
Synonym:

sulfamethin; sulfaisodimidine

Size Price Availability Quantity
100mg USD 60  USD60 In stock
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Quality Control & Documentation
Biological Activity

Sulfisomidin is a sulfonamide antibacterial.

Chemical Information
Molecular Weight 278.33
Formula C12H14N4O2S
CAS Number 515-64-0
Solubility (25°C) DMSO 55 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yoshiaki Kitamura, et al. Bioorg Med Chem Lett. Sulfonamide antibiotics inhibit RNAi by binding to human Argonaute protein 2 PAZ

[2] No authors listed. J Am Med Assoc. SULFISOMIDINE

[3] S S Yang, et al. J Pharm Sci. Polymorphism in sulfonamides

[4] K Holmberg, et al. Scand J Infect Dis. Antimicrobial in vitro susceptibility of actinomyces israelii and arachnia propionica

[5] B M Andersen. Scand J Infect Dis. Mortality in meningococcal infections

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