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Substance P (6-11) is the C-terminal hexapeptideamide of Substance P. Substance P (6-11) binds to NK-1 tachykinin receptor. Substance P (6-11) shows depolarization of motoneurons and a hypotensive effect.
In vivo, Substance P (6-11) (0.1-10 nM) inhibits insulin and glucagon secretion from the rat pancreas in a dose-dependent manner. By contrast, Substance P (6-11) (1-10 nM) potentiates the release of insulin, glucagon and somatostatin in the canine pancreas.
| Molecular Weight | 740.91 |
| Formula | C36H52N8O7S |
| CAS Number | 51165-07-2 |
| Storage | -20°C, sealed |
| Related Neurokinin Receptor Products |
|---|
| GR203040
GR203040 is an orally active NK1 receptor antagonist with a pKi of 10.3. |
| Ezlopitant
Ezlopitant (CJ-11,974) is a selective, non-peptidic neurokinin-1 (NK-1)-receptor antagonist. |
| CP 122721 hydrochloride
CP 122721 hydrochloride is a potent, non-peptide and selective nonpeptide neurokinin NK1 antagonist, with a pIC50 of 9.8 for human NK1 receptor expressed in IM-9 cells. |
| Spantide II
Spantide II, an undecapeptide substance P (SP) analog, is a potent neurokinin-1 receptor (NK-1R) antagonist. |
| Substance P (7-11)
Substance P (7-11) is a C-terminal fragment of Substance P which can cause an increase in the intracellular calcium concentration. |
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