Expression system: E. coli
Purity: SDS-PAGE Analysis > 95%
Theoretical molecular weight: 13500 Da
Storage and stability: the powder can be stored for several weeks at 4 ° C. For long-term storage, please store it at -20 ° C.
Biological activity: >15 u/mg protein, 1 u is defined as the amount of 1 microgram of protein bound. Streptavidin can bind to four moles of biotin per mole of protein and shows a very high affinity, about 10000-15000 da. Streptavidin lacks the carbohydrate side chain on the avidin, and its isoelectric point is 6.5 to 10, which is far closer to the point where the most useful biological interaction occurs. Therefore, streptavidin usually exhibits much lower nonspecific binding than avidin.
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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