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STL1267 is a potent REV-ERB agonist that crosses the blood-brain barrier with a Ki value of 0.16 µM for REV-ERBα. STL1267 showed no cytotoxicity and inhibited BMAL1 gene expression.
| Molecular Weight | 322.75 |
| Formula | C17H11ClN4O |
| CAS Number | 1429024-58-7 |
| Form | Solid |
| Solubility (25°C) | DMSO 25 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Mohammad Homaidur Rahman, et al. Sci Rep. Mechanism of antagonist ligand binding to REV-ERBα
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