About 15 results found for searched term "REV-ERB" (0.129 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M5143 | Stenabolic (SR9009) | REV-ERB |
| Stenabolic; REV-ERB Agonist II | ||
| Stenabolic (SR9009) is an agonist of REV-ERB, with IC50 of 670 nM and 800 nM for REV-ERBα and REV-ERBβ respectively. | ||
| M1667 | Sapitinib (AZD8931) | EGFR/HER2 |
| AZD-8931 | ||
| AZD8931 (Sapitinib) is an equipotent, reversible inhibitor of Signaling by EGFR, ERBB2 (HER2), and ERBB3 with IC50 of 4, 3, 4 nM respectively. | ||
| M1943 | Canertinib | EGFR/HER2 |
| CI-1033, PD-183805 | ||
| Canertinib (CI-1033) is an irreversible tyrosine-kinase inhibitor with activity against EGFR (IC50 0.8 nM), HER-2 (IC50 19 nM) and ErbB-4 (IC50 7 nM). | ||
| M3569 | AST-1306 (TsOH) | EGFR/HER2 |
| AST-6; Allitinib tosylate | ||
| AST-1306 is a novel irreversible inhibitor of EGFR and ErbB2 with IC50 of 0.5 nM and 3 nM, also effective in mutation EGFR T790M/L858R, more potent to ErbB2-overexpressing cells, 3000-fold selective for ErbB family than other kinases, | ||
| M5346 | WZ3146 | EGFR/HER2 |
| WZ3146 is a mutant-selective irreversible inhibitor of EGFR(L858R) and EGFR(E746_A750) with IC50 of 2 nM and 2 nM; does not inhibit ERBB2 phosphorylation (T798I). | ||
| M5678 | SR8278 | REV-ERB |
| SR-8278 | ||
| SR8278 represents a unique chemical tool for probing REV-ERB function and may serve as a point for initiation of further optimization to develop REV-ERB antagonists with the ability to explore circadian and metabolic functions. | ||
| M6773 | GSK 4112 | REV-ERB |
| SR6452 | ||
| GSK 4112 is a selective Rev-Erbα agonist with an EC50 value of 0.4 μM, which can be used to explore the function of Rev-erbα in transcriptional repression, biological regulation of circadian rhythms and metabolic pathways. | ||
| M7322 | SR 10067 | REV-ERB |
| SR 10067 is a selective Rev-Erbα/β agonist; anxiolytic. | ||
| M9562 | Huperzine A | AChR/AChE |
| (±)-Huperzine A | ||
| Huperzine A is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor extracted from traditional Chinese herb. | ||
| M14775 | SR9011 | REV-ERB |
| SR9011 is a REV-ERBα/β agonist with IC50s of 790 nM and 560 nM for REV-ERBα and REV-ERBβ, respectively. | ||
| M14776 | SR9011 hydrochloride | REV-ERB |
| SR9011 hydrochloride is a REV-ERBα/β agonist with IC50s of 790 nM and 560 nM for REV-ERBα and REV-ERBβ, respectively. | ||
| M28106 | Selatinib | EGFR/HER2 |
| Selatinib is a reversible and orally active dual EGFR and ErbB2 inhibitor with IC50s of 13 nM and 22.5 nM, respectively. Selatinib has anticancer effects. | ||
| M45382 | STL1267 | REV-ERB |
| STL1267 is a potent REV-ERB agonist that crosses the blood-brain barrier with a Ki value of 0.16 µM for REV-ERBα. STL1267 showed no cytotoxicity and inhibited BMAL1 gene expression. | ||
| M45383 | SR-29065 | REV-ERB |
| SR-29065 is a selective REV-ERBα agonist for autoimmune disease research. | ||
| M45384 | SR12418 | REV-ERB |
| SR12418 is a REV-ERB-specific synthetic ligand with IC50 values of 68 nM for REV-ERBα and 119 nM for REV-ERBβ. SR12418 can be used in studies related to experimental autoimmune encephalomyelitis (EAE) and colitis. | ||
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