Stiripentol can be used in the third generation of anti-epileptic studies that enhance gabaergic neurotransmission. Due to its inhibition of several cytochrome P450 enzymes, it has a wide range of pharmacokinetic interactions. Stiripentol also has neuroprotective effects, reducing calcium-mediated neurotoxicity. Stiripentol is also a compound used to study inhibition of neuronal LDH-5 isozyme activity.
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
Molecular Weight | 234.29 |
Formula | C14H18O3 |
CAS Number | 49763-96-4 |
Purity | 99.92% |
Solubility | DMSO ≥ 30 mg/mL |
Storage | at -20°C |
[1] No authors listed. Med Lett Drugs Ther. Stiripentol (Diacomit) for Dravet syndrome
[2] No authors listed. Aust Prescr. Stiripentol for Dravet syndrome
[3] No authors listed. Stiripentol
[4] James E Frampton. Stiripentol: A Review in Dravet Syndrome
Related Cytochrome P450 (e.g. CYP17) Products |
---|
Naringin
Naringin, a flavanone glycoside, exerts various of pharmacological effects such as blood lipid lowering, antioxidant activity, anticancer activity, and inhibition of cytochrome P450 enzymes. |
Tebuconazole
Tebuconazole is an agricultural azole fungicide that also inhibits CYP51 for Candida albicans CYP51 (CaCYP51) and truncated human CYP51 (Δ60HsCYP51). IC50 The values are 0.9 and 1.3 μM, respectively. |
Uniconazole
Uniconazole is a plant growth regulator that inhibits cytochrome P450 707As (Ki=68 nM) plays a role, which is a family of enzymes that separate abscisic acid and therefore inhibits the biosynthesis of gibberellin and sterols. |
Dihydromethysticin
Dihydroestherol (Dihydromethysticin) kava lactone, with induced CYP3A23 activity. |
Bergaptol
Bergaptol is a hydroxylated psoralen that acts as a potent inhibitors of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 uM. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.