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Stiripentol can be used in the third generation of anti-epileptic studies that enhance gabaergic neurotransmission. Due to its inhibition of several cytochrome P450 enzymes, it has a wide range of pharmacokinetic interactions. Stiripentol also has neuroprotective effects, reducing calcium-mediated neurotoxicity. Stiripentol is also a compound used to study inhibition of neuronal LDH-5 isozyme activity.
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Molecular Weight | 234.29 |
| Formula | C14H18O3 |
| CAS Number | 49763-96-4 |
| Purity | 99.92% |
| Solubility | DMSO ≥ 30 mg/mL |
| Storage | at -20°C |
[1] No authors listed. Med Lett Drugs Ther. Stiripentol (Diacomit) for Dravet syndrome
[2] No authors listed. Aust Prescr. Stiripentol for Dravet syndrome
[3] No authors listed. Stiripentol
[4] James E Frampton. Stiripentol: A Review in Dravet Syndrome
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