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SPR inhibitor 3 (SPRi3) is a potent sepiapterin reductase (SPR) inhibitor. SPR inhibitor 3 (SPRi3) displays high binding affinity to human SPR in a cell-free assay (IC50=74 nM) and efficiently reduces biopterin levels in a cell-based assay (IC50=5.2 μM). SPR inhibitor 3 (SPRi3) reduces neuropathic and inflammatory pain through a reduction of BH4 levels.
| Molecular Weight | 262.3 |
| Formula | C14H18N2O3 |
| CAS Number | 1292285-54-1 |
| Form | Solid |
| Solubility (25°C) | DMSO 100 mg/mL (ultrasonic) |
| Storage | -20°C, sealed |
[3] Yuan Fang, et al. Acta Pharm Sin B. Natural products as LSD1 inhibitors for cancer therapy
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