Free shipping on all orders over $ 500

Spliceostatin A 

Cat. No. M30035

All AbMole products are for research use only, cannot be used for human consumption.

Spliceostatin A  Structure

Price and Availability

For this product's availability, delivery time and price, please email [email protected] directly or click the "Inquiry Now" button below.

Quality Control & Documentation
Biological Activity

Spliceostatin A, the FR901464 methylated derivative, is a potent anti-tumor agent. Spliceostatin A inhibits splicing and promotes pre-mRNA accumulation by binding SF3B1. SF3B1 is a subcomplex of U2 small nuclear ribonucleoprotein in the spliceosome. Spliceostatin A induces Apoptosis in chronic lymphocytic leukemia (CLL) cells.

Chemical Information
Molecular Weight 521.64
Formula C28H43NO8
CAS Number 391611-36-2
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Joanna Bajsa-Hirschel, et al. Front Plant Sci. Spliceostatin C, a component of a microbial bioherbicide, is a potent phytotoxin that inhibits the spliceosome

[2] Daisuke Kaida, et al. Biochem Biophys Res Commun. Spliceostatin A stabilizes CDKN1B mRNA through the 3' UTR

[3] Rei Yoshimoto, et al. Cell Chem Biol. Spliceostatin A interaction with SF3B limits U1 snRNP availability and causes premature cleavage and polyadenylation

[4] Daisuke Kaida. Biochem Biophys Res Commun. Spliceostatin A treatment inhibits mitotic clonal expansion and adipogenesis

[5] Arun K Ghosh, et al. Org Lett. Enantioselective Synthesis of a Cyclopropane Derivative of Spliceostatin A and Evaluation of Bioactivity

Related Products
DSPE-PEG-FA

DSPE-PEG2K-FA is a PEG derivative containing folic acid. DSPE-PEG2K-FA has a targeting effect and can bind to folic acid receptors in cancer cells. DSPE-PEG2K-FA forms micelles/lipid bilayers and can be used in research on targeted drug delivery systems.
Lifastuzumab

Lifastuzumab is a humanized anti-NaPi2b IgG1 monoclonal antibody.
GPVI antagonist 1

GPVI antagonist 1 is a glycoprotein VI (GPVI) platelet receptor antagonist. GPVI antagonist 1 inhibits collagen-induced platelet aggregation with an IC50 of 25.3 μM.
MPSD TFA

MPSD TFA (MARCKS-ED TFA) is a 25-amino acid peptide based on the effector domain sequence of the intracellular membrane protein myristoylated alanine-rich C-kinase substrate (MARCKS). MPSD TFA can sense membrane curvature and recognize phosphatidylserine. MPSD TFA can be utilized as biological probe to study membrane shape and lipid composition.
4-Nitro-2,1,3-benzoselenadiazole

4-Nitro-2,1,3-benzoselenadiazole is a biochemical material that can be used in scientific research.
  Catalog
Abmole Inhibitor Catalog




Keywords: Spliceostatin A  supplier, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
Get to Know Us
Customer Support
Resources
Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.