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Spliceostatin A, the FR901464 methylated derivative, is a potent anti-tumor agent. Spliceostatin A inhibits splicing and promotes pre-mRNA accumulation by binding SF3B1. SF3B1 is a subcomplex of U2 small nuclear ribonucleoprotein in the spliceosome. Spliceostatin A induces Apoptosis in chronic lymphocytic leukemia (CLL) cells.
| Molecular Weight | 521.64 |
| Formula | C28H43NO8 |
| CAS Number | 391611-36-2 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
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