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Spliceostatin A 

Cat. No. M30035

All AbMole products are for research use only, cannot be used for human consumption.

Spliceostatin A  Structure

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Quality Control & Documentation
Biological Activity

Spliceostatin A, the FR901464 methylated derivative, is a potent anti-tumor agent. Spliceostatin A inhibits splicing and promotes pre-mRNA accumulation by binding SF3B1. SF3B1 is a subcomplex of U2 small nuclear ribonucleoprotein in the spliceosome. Spliceostatin A induces Apoptosis in chronic lymphocytic leukemia (CLL) cells.

Chemical Information
Molecular Weight 521.64
Formula C28H43NO8
CAS Number 391611-36-2
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Joanna Bajsa-Hirschel, et al. Front Plant Sci. Spliceostatin C, a component of a microbial bioherbicide, is a potent phytotoxin that inhibits the spliceosome

[2] Daisuke Kaida, et al. Biochem Biophys Res Commun. Spliceostatin A stabilizes CDKN1B mRNA through the 3' UTR

[3] Rei Yoshimoto, et al. Cell Chem Biol. Spliceostatin A interaction with SF3B limits U1 snRNP availability and causes premature cleavage and polyadenylation

[4] Daisuke Kaida. Biochem Biophys Res Commun. Spliceostatin A treatment inhibits mitotic clonal expansion and adipogenesis

[5] Arun K Ghosh, et al. Org Lett. Enantioselective Synthesis of a Cyclopropane Derivative of Spliceostatin A and Evaluation of Bioactivity

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Keywords: Spliceostatin A  supplier, inhibitors, activators

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