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Sphingosine-1-phosphate

Cat. No. M7319
Sphingosine-1-phosphate Structure
Size Price Availability
5mg USD 486  USD540 Out of stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Sphingosine-1-phosphate is a endogenous second messenger involved in the control of cell proliferation and motility, and Ca2+ mobilization. Acts as an agonist at sphingosine-1-phosphate receptors (S1P1-5) and as an activator of GPR3, GPR6 and GPR12. Effectors regulated include p38 MAP kinase, PLC, adenylyl cyclase, myosin light chain phosphatase and focal adhesion kinase.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 379.48
Formula C18H38NO5P
CAS Number 26993-30-6
Purity >98%
Solubility
Storage -20°C, dry, protect from light, sealed
References

Structural and functional characteristics of S1P receptors
Teresa Sanchez, et al. J Cell Biochem. 2004 Aug 1;92(5):913-22. PMID: 15258915.

Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors
Kirsten Uhlenbrock, et al. Cell Signal. 2002 Nov;14(11):941-53. PMID: 12220620.

Subtype selectivity of peptide analogs for all five cloned human somatostatin receptors (hsstr 1-5).
Patel and Srikant. Endocrinology. 1994;135: 2814. PMID: 7988476.

Related S1P Receptor Products
Etrasimod (APD334)

Etrasimod (APD334) is a specific and orally available antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor, with IC50 of 1.88 nM in CHO cells.

PF-543 Citrate

PF-543 Citrate is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC50 of 2 nM and a Ki of 3.6 nM.

Opaganib (ABC294640)

Opaganib (ABC294640) is an orally bioavailable and selective sphingosine kinase-2 (SphK2) inhibitor with IC50 of approximately 60 μM.

NIBR-0213

NIBR-0213 is an orally active, potent and S1P1-selective sphingosine 1-phosphate (S1P) receptor antagonist.

A-971432

A-971432 is an orally bioavailable, non-clastogenic, azetidinecarboxylate compound that acts as a highly potent and selective sphingosine-1-phosphate receptor 5 agonist (IC50 = 6 nM/S1P5, 362 nM/S1P1 and >10 μM/S1P3 in a radio-ligand binding assay).

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Sphingosine-1-phosphate supplier, S1P Receptor, inhibitors

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