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SPA0355 inhibits cytokine and LPS-induced activation of NF-kB in cell-based assays, blocking IKK-2 phosphorylation, degradation, and p65 binding to DNA. In vivo, SPA0355 inhibits paw edema and joint destruction in a mouse collagen induced arthritis model.
| Molecular Weight | 391.49 |
| Formula | C22H21N3O2S |
| CAS Number | 1251839-15-2 |
| Solubility (25°C) | DMSO: 15 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Sang Hoon Kim, et al. SPA0355 prevents ovariectomy-induced bone loss in mice
[4] Ui-Jin Bae, et al. SPA0355 attenuates ischemia/reperfusion-induced liver injury in mice
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