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Sorbinil

Cat. No. M8190

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Sorbinil Structure

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Quality Control & Documentation
Biological Activity

Sorbinil decreases the level of sorbitol in red blood cells and increases the velocity of nerve conduction. It maintains the myo-inositol content in the nerve and prevents the reduction of sodium-potassium ATPase activity. This action is beneficial in providing symptomatic relief in patients with diabetic neuropathy.1,2

Chemical Information
Molecular Weight 236.2
Formula C11H9FN2O3
CAS Number 68367-52-2
Solubility (25°C) DMSO: ≥20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Qi Huang, et al. Sorbinil, an Aldose Reductase Inhibitor, in Fighting Against Diabetic Complications

[2] A Beyer-Mears, et al. Comparison of the effects of Zopolrestat and Sorbinil on lens myo-inositol influx

[3] A Beyer-Mears, et al. Sorbinil protection of lens protein components and cell hydration during diabetic cataract formation

[4] R S Clements Jr. Review of myo-inositol and sorbinil studies

[5] M J Crabbe, et al. The penetration of Sorbinil, an aldose reductase inhibitor, into lens, aqueous humour and erythrocytes of patients undergoing cataract extraction

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Keywords: Sorbinil supplier, inhibitors, activators

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