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Antibacterial Solithromycin binds to the large 50S subunit of the ribosome and inhibits protein biosynthesis. The mean 50% inhibitory concentrations (IC50s) for Solithromycin inhibition of cell viability, protein synthesis, and growth rate were 7.5, 40, and 125 ng/ml for Streptococcus pneumoniae,Staphylococcus aureus, and Haemophilus influenzae, respectively.
| Cell Experiment | |
|---|---|
| Cell lines | S. aureus cells |
| Preparation method | For S. pneumoniae, 12 9-ml cultures of cells comprised of one control set and one set with solithromycin at 7.5 ng/ml were grown to a Klett reading of 15. |
| Concentrations | 7.5 ng/ml |
| Incubation time | 15-min |
| Animal Experiment | |
|---|---|
| Animal models | donor mic |
| Formulation | DMSO |
| Dosages | 100 mg/kg |
| Administration | i.v. |
| Molecular Weight | 845.01 |
| Formula | C43H65FN5O10 |
| CAS Number | 760981-83-7 |
| Form | Solid |
| Solubility (25°C) | 32 mg/mL in DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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