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Solifenacin succinate

Cat. No. M3025
Solifenacin succinate Structure
Synonym:

YM905

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mg USD 38.7  USD43 In stock
50mg USD 51.3  USD57 In stock
100mg USD 90  USD100 In stock
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Quality Control
Biological Activity

Solifenacin succinate is a urinary antispasmodic of the antimuscarinic class. In murine submandibular gland cells, the antagonistic effects of 100 nM Solifenacin Succinate and oxybutynin on Ca2+ mobilization evoked by varying doses of carbachol (CCh) are examined. In vivo, Solifenacin Succinate (YM905) reduces bladder responses by 40% at a dose of 210 nmol/kg (0.1 mg/kg) and abolishes them at 2100 nmol/kg (1 mg/kg).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 480.55
Formula C23H26N2O.C4H6O4
CAS Number 242478-38-2
Purity >99%
Solubility Water 60 mg/mL
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Solifenacin succinate, YM905 supplier, AChR/AChE, inhibitors

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