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Solifenacin succinate

Cat. No. M3025
Solifenacin succinate Structure
Synonym:

YM905

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mg USD 43  USD43 In stock
50mg USD 57  USD57 In stock
100mg USD 100  USD100 In stock
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Quality Control & Documentation
Biological Activity

Solifenacin succinate is an anti-muscarinic urinary spasmolysis compound.

Chemical Information
Molecular Weight 480.55
Formula C23H26N2O.C4H6O4
CAS Number 242478-38-2
Solubility (25°C) Water 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jipeng Wang, et al. Meta-analysis of the efficacy and safety of mirabegron and solifenacin monotherapy for overactive bladder

[2] Christian Gratzke, et al. Long-term Safety and Efficacy of Mirabegron and Solifenacin in Combination Compared with Monotherapy in Patients with Overactive Bladder: A Randomised, Multicentre Phase 3 Study (SYNERGY II)

[3] Susan Hoffstetter, et al. Solifenacin succinate for the treatment of overactive bladder

[4] Maria Maniscalco, et al. Solifenacin succinate for the treatment of symptoms of overactive bladder

[5] Karl J Kreder. Solifenacin

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