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Solcitinib

Cat. No. M7551
Solcitinib Structure
Synonym:

GSK-2586184; GLPG-0778

Size Price Availability Quantity
5mg USD 85  USD85 In stock
10mg USD 110  USD110 In stock
50mg USD 240  USD240 In stock
100mg USD 390  USD390 In stock
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Quality Control & Documentation
Biological Activity

Solcitinib is an oral, competitive, potent, and selective JAK1 inhibitor with an IC50 value of 9.8 nM, which is 11,55, and 23 times more selective than JAK2, JAK3, and TYK2. Solcitinib can be used in studies of psoriasis.

Chemical Information
Molecular Weight 389.45
Formula C22H23N5O2
CAS Number 1206163-45-2
Solubility (25°C) 20 mg/mL in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Adwan MH Curr Rheumatol Rep. Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome and the Rheumatologist.

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  Catalog
Abmole Inhibitor Catalog




Keywords: Solcitinib, GSK-2586184; GLPG-0778 supplier, JAK, inhibitors, activators


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