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SM-7368

Cat. No. M8347

All AbMole products are for research use only, cannot be used for human consumption.

SM-7368 Structure

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Biological Activity

SM-7368 is a cell-permeable inhibitor of TNF-α-induced MMP-9 upregulation. Also, SM-7368 strongly inhibits TNF-α-induced NF-kB activity but not AP-1 activity. The compound inhibits the TNF-α-induced invasion of HT1080 human fibrosarcoma cell line.

Chemical Information
Molecular Weight 328.69
Formula C10H5ClN4O5S
CAS Number 380623-76-7
Solubility (25°C) DMSO: 10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Xiaofei Wang, et al. Regulation of a disintegrins and metalloproteinase with thrombospondin motifs 7 during inflammation in nucleus pulposus (NP) cells: role of AP-1, Sp1 and NF-κB signaling

[2] Temesgen Samuel, et al. Variable NF-κB pathway responses in colon cancer cells treated with chemotherapeutic drugs

[3] Sabine Kuntz, et al. Carbonyl compounds methylglyoxal and glyoxal affect interleukin-8 secretion in intestinal cells by superoxide anion generation and activation of MAPK p38

[4] Melissa J Mulla, et al. Regulation of Nod1 and Nod2 in first trimester trophoblast cells

[5] Ha Young Lee, et al. A small compound that inhibits tumor necrosis factor-alpha-induced matrix metalloproteinase-9 upregulation

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Keywords: SM-7368 supplier, inhibitors, activators

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