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SKF38393 HCl

Cat. No. M9022
SKF38393 HCl Structure


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Quality Control
Biological Activity

SKF38393 hydrochloride is a selective agonist of the D1DR (dopamine D1 receptor). SKF-38393 HCl is an activator of D5DR. SKF38393 is a synthetic compound of the benzazepine chemical class which acts as a selective D1/D5 receptor partial agonist. SKF38393 HCl has stimulant and anorectic effects. SKF-38393 hydrochloride enhances the frequency of mEPSCs in a concentration-dependent manner.

Cell Experiment
Cell lines MCF-7, MDA-MB231 and MCF-10 cells
Preparation method Examine the effects of a specific dopamine agonist, SKF 38393, against MCF-7 cells. MDA-MB231 and MCF-10 cells were used as negative controls. The breast cancer in vitro screening procedure involved the plating of MCF-7, MDA-MB231 and MCF-10 cells in a 96-well plate assay. After 1 day, the cells were exposed to SKF 38393 for 2 days and cell growth was determined by the Alamar blue dye reagent method. The optical density data was analyzed and IC50 values determined. The results indicated that SKF 38393 caused a significant decrease in proliferation of MCF-7 cells. The IC50 value was 0.1 +/- 0.03 mu M. The results also indicated no significant effect on MDA-MB231 and MCF-10 cells.
Incubation time 2 days
Animal Experiment
Animal models Male Wistar rats
Formulation saline
Dosages 6 mg/kg
Administration i.p.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 291.77
Formula C16H17NO2.HCl
CAS Number 62717-42-4
Purity 99.80%
Solubility DMSO: ≥ 30 mg/mL
Storage at -20°C

Role of the basolateral amygdala dopamine receptors in arachidonylcyclopropylamide-induced fear learning deficits.
Nasehi M, et al. Psychopharmacology (Berl). 2016 Jan;233(2):213-24. PMID: 26546370.

Differential effects of dopamine signalling on long-term memory formation and consolidation in rodent brain.
Reichenbach N, et al. Proteome Sci. 2015 Mar 18;13:13. PMID: 25852303.

Performance- and task-dependent effects of the dopamine D1/D5 receptor agonist SKF 38393 on learning and memory in the rat.
Amico F, et al. Eur J Pharmacol. 2007 Dec 22;577(1-3):71-7. PMID: 17900561.

Dopamine D1/D5 receptor activation modulates a persistent sodium current in rat prefrontal cortical neurons in vitro.
Gorelova NA, et al. J Neurophysiol. 2000 Jul;84(1):75-87. PMID: 10899185.

Picomolar affinity of 125I-SCH 23982 for D1 receptors in brain demonstrated with digital subtraction autoradiography.
Altar CA, et al. J Neurosci. 1987 Jan;7(1):213-22. PMID: 2949066.

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Keywords: SKF38393 HCl, SKF-38393A supplier, Dopamine Receptor, inhibitors

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