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SKF38393 hydrochloride is a selective agonist of the D1DR (dopamine D1 receptor). SKF-38393 HCl is an activator of D5DR. SKF38393 is a synthetic compound of the benzazepine chemical class which acts as a selective D1/D5 receptor partial agonist. SKF38393 HCl has stimulant and anorectic effects. SKF-38393 hydrochloride enhances the frequency of mEPSCs in a concentration-dependent manner.
| Cell Experiment | |
|---|---|
| Cell lines | MCF-7, MDA-MB231 and MCF-10 cells |
| Preparation method | Examine the effects of a specific dopamine agonist, SKF 38393, against MCF-7 cells. MDA-MB231 and MCF-10 cells were used as negative controls. The breast cancer in vitro screening procedure involved the plating of MCF-7, MDA-MB231 and MCF-10 cells in a 96-well plate assay. After 1 day, the cells were exposed to SKF 38393 for 2 days and cell growth was determined by the Alamar blue dye reagent method. The optical density data was analyzed and IC50 values determined. The results indicated that SKF 38393 caused a significant decrease in proliferation of MCF-7 cells. The IC50 value was 0.1 +/- 0.03 mu M. The results also indicated no significant effect on MDA-MB231 and MCF-10 cells. |
| Concentrations | |
| Incubation time | 2 days |
| Animal Experiment | |
|---|---|
| Animal models | Male Wistar rats |
| Formulation | saline |
| Dosages | 6 mg/kg |
| Administration | i.p. |
| Molecular Weight | 291.77 |
| Formula | C16H17NO2.HCl |
| CAS Number | 62717-42-4 |
| Solubility (25°C) | DMSO: ≥ 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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