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SKF 83822 hydrobromide

Cat. No. M7302

All AbMole products are for research use only, cannot be used for human consumption.

SKF 83822 hydrobromide Structure

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Quality Control & Documentation
Biological Activity

SKF 83822 hydrobromide is a high affinity, selective dopamine D1-like receptor agonist. Ki values are 3.2, 3.1, 186, 66, 335, 1167, 1251 and 1385 nM at recombinant D1, D5, D2, D3, D4, 5-HT2A, α1A and α1B receptors respectively. Stimulates adenylyl cyclase (EC50 = 65 nM) but not phosphoinositide hydrolysis. Induces extreme arousal and hyperlocomotion following subcutaneous administration in monkeys.

Chemical Information
Molecular Weight 424.76
Formula C20H22ClNO2.HBr
CAS Number 74115-10-9
Solubility (25°C) DMSO 34.38 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Bridger, et al. J Med Chem. Synthesis and structure-activity relationships of phenylenebis(methylene)-linked bis-tetraazamacrocycles that inhibits HIV replication Effects of macrocyclic ring size and substituents on the aromatic linker.

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