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Silvestrol

Cat. No. M13664

All AbMole products are for research use only, cannot be used for human consumption.

Silvestrol Structure
Synonym:

(-)-Silvestrol

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Quality Control & Documentation
Biological Activity

Silvestrol is a eukaryotic translation initiation factor 4A (eIF4A) inhibitor isolated from the fruits and twigs of Aglaia foveolata. Silvestrol induces autophagy and caspase-mediated apoptosis.

Chemical Information
Molecular Weight 654.66
CAS Number 697235-38-4
Solubility (25°C)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Thomas E Webb, et al. Clin Transl Radiat Oncol. The eIF4A inhibitor silvestrol sensitizes T-47D ductal breast carcinoma cells to external-beam radiotherapy

[2] Gran Schulz, et al. Nat Prod Rep. Rocaglamide and silvestrol: a long story from anti-tumor to anti-coronavirus compounds

[3] Leonard Blum, et al. J Cell Mol Med. Natural antiviral compound silvestrol modulates human monocyte-derived macrophages and dendritic cells

[4] Lisa Henss, et al. Viruses. Silvestrol Inhibits Chikungunya Virus Replication

[5] Li Pan, et al. Nat Prod Rep. Rocaglamide, silvestrol and structurally related bioactive compounds from Aglaia species

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Keywords: Silvestrol, (-)-Silvestrol supplier, inhibitors, activators

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