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Sibofimloc

Cat. No. M21494
Sibofimloc Structure
Synonym:

Antibiotic-202

Size Price Availability Quantity
5mg USD 150  USD150 In stock
10mg USD 220  USD220 In stock
50mg USD 540  USD540 In stock
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Quality Control & Documentation
Biological Activity

Sibofimloc (CD-202) is a first-in-class, intestinal limiting and oral active inhibitor of FimH adhesion. Sibofimloc has antibacterial activity and is being developed for the study of inflammatory bowel disease (IBD).

Chemical Information
Molecular Weight 649.68
Formula C35H39NO11
CAS Number 1616113-45-1
Form Solid
Solubility (25°C) DMSO ≥ 20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Walter Reinisch, et al. J Gastroenterol Hepatol. Safety, pharmacokinetic, and pharmacodynamic study of sibofimloc, a novel FimH blocker in patients with active Crohn's disease

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  Catalog
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Keywords: Sibofimloc, Antibiotic-202 supplier, Antibiotic, inhibitors, activators


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