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Shield-1 is a specific, cell-permeant and high-affinity ligand of FK506-binding protein-12 (FKBP), and reverses the instability by binding to mutated FKBP. Shield-1 can stabilize proteins tagged with a mutated FKBP12-derived destabilization domain (DD)
| Molecular Weight | 748.9 |
| Formula | C42H56N2O10 |
| CAS Number | 914805-33-7 |
| Solubility (25°C) | DMSO ≥ 65 mg/mL (ultrasonic and warming) |
| Storage | -20°C, sealed |
| Related FKBP (FK506-binding protein) Products |
|---|
| dTAGV-1 hydrochloride
dTAGV-1 hydrochloride is the hydrochloride form of dTAGV-1 that is a small molecule degrader of FKBP12. |
| Suc-Ala-Leu-Pro-Phe-pNA
Suc-Ala-Leu-Pro-Phe-pNA (Suc-ALPF-pNA) is a substrate of FK-506 binding protein (FKBP). |
| RapaBlock
RapaBlock is a potent, non-immunosuppressive and brain-impermeable FKBP12 ligand. |
| FKBP51F67V-selective antagonist Ligand2
FKBP51F67V-selective antagonist Ligand2 is a potent FKBP51 F67V-selective antagonist ligand. |
| dTAGV-1-NEG TFA
dTAGV-1-NEG TFA is a diastereomer and as a heterobifunctional negative control of dTAGV-1. dTAGV-1-NEG TFA is an FKBP12F36V-selective degrader. |
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